DR. RUMA DEY GHOSH

PhD (PhD Senior Scientist 2021 onwards)

Expertise

DR. RUMA DEY GHOSH

Senior Scientist (2021 onwards)

 

Phone: 033 71223000 Extn. 220

Email: deyrumai@yahoo.co.in; rumadeyghosh.nscri@gmail.com

 

PhD: The University of Burdwan

Postdoc: Uniformed Services University of Health Sciences, Maryland, USA.

Scientist (PI): Chittaranjan National Cancer Institute, Kolkata

Scientist (PI): Indian Institute of Chemical Biology, Kolkata

Scientist (PI): Tata Translational Cancer Research Center, Tata Medical Center, Kolkata

 

Current Lab Members:        Priyanka Adhikary, JRF (CU, Biochemistry)

                                                Puloma Dhar, Project Technician (MAKAUT, Microbiology)

                                                Sounetra Choudhury, JRF (MAKAUT, Molecular Biology)

                                                Arijit Ghosh, Field Assistant (VU, Biochemistry) 

 

Research Intern Trained:     17 Past Students, and 1 ongoing student.

 

Expertise:

 

I have expertise in constructing research problems that have a translational impact on cancer disease management. I am working around identifying the non-invasive blood-based biomarkers for liquid biopsy mainly by profiling circulating proteomes, miRNAomes, and lncRNAomes molecules to predict cancer prognosis more accurately robustly, and cost-effectively. Currently, we are working on Breast cancers and Oral cancers.

 

Major Research Interests:

 

My research interests are to identify genetic and epigenetic alterations that play a role in cancer malignancies and to determine their clinical importance. Mainly to explore the biology of different non-coding RNA-mediated regulation of gene expression and its alteration during disease progression to understand their role in differential prognostic outcomes in patients with oral cancer and to work on preventive mechanisms through RNA-based therapeutic approaches to treat cancer.

 

To overcome the therapeutic resistance to cancer by using some novel agents (natural or synthetic).

 

List of Publications

 

  1. Dey Ghosh, R.; Guha Majumder, S. Circulating Long Non-Coding RNAs Could Be the Potential Prognostic Biomarker for Liquid Biopsy for the Clinical Management of Oral Squamous Cell Carcinoma. Cancers 2022, 14, 5590. https://doi.org/10.3390/cancers14225590 ; Impact Factor : 6.575

 

  1. Ruma Dey Ghosh*, Pattathyeil Arun and Susanta Roychoudhury. Functional landscape of dysregulated microRNAs in oral squamous cell carcinoma: clinical implications. Review Article published in Frontiers in Oncology. 12 May 2020  https://doi.org/10.3389/fonc.2020.00619, Vol. 10, Article 619. * Corresponding author. IF 6.244.

 

  1. Ruma Dey Ghosh*, Bararia A, Majumder SG, Manickam A, Bhutia TY, Jain P, Manikantan K, Sharan R, Arun P. Cell-free mature miR-100-5p expression in plasma and its correlation with the histopathological markers in oral squamous cell carcinoma. November 2019, DOI: 10.1201/9781003001614-29, In book: Biotechnology and Biological Sciences. Taylor & Francis publication, CRC Press London. https://doi.org/10.1201/9781003001614. * Corresponding author.

 

  1. Ruma Dey Ghosh*, Sangeeta Ghuwalewala, Pijush Das, Sapan Mandoloi, Sk Kayum Alam, Jayanta Chakraborty, Sajal Sarkar, Saikat Chakraborty, Chinmoy Kumar Panda and Susanta Roychoudhury. MicroRNA profiling of cisplatin-resistant oral squamous cell carcinoma cell lines enriched with CSC-like and EMT-type features. Scientific Reports, 6: 23932, 2016. * Corresponding author. IF: 4.01

 

  1. Dey Ghosh R, Banerjee K, Das S, Ganguly A, Chakraborty P, Sarkar A, Chatterjee M, Choudhuri SK. A Novel Manganese Complex, Mn-(II) N-(2-Hydroxy Acetophenone) Glycinate overcomes Multidrug-Resistance in Cancer. European Journal of Pharmaceutical Sciences, 49: 737-747, 2013. (ISSN: 0928-0987).  IF: 3.773

 

  1. Dey Ghosh R, Chakraborty P, Banerjee K, Adhikari A, Sarkar A, Chatterjee M, Das T, Choudhuri SK. The molecular interaction of a copper chelate with human P-glycoprotein. Mol Cell Biochem, 364: 309-320, 2012. (ISSN: 0300-8177) IF: 2.795

 

  1. Dey Ghosh R, Das S, Ganguly A, Banerjee K, Chakraborty P, Sarkar A, Chatterjee M, Nanda A, Pradhan K, Choudhuri SK. An In Vitro and In Vivo Study of a Novel Zinc Complex, Zinc N-(2-Hydroxy Acetophenone) Glycinate to Overcome Multidrug Drug-Resistance in Cancer. Dalton Transactions, 40, 10873-10884, 2011. (ISSN: 1477-9226). IF: 4.052

 

  1. Choudhuri SK, Majumder S, Chatterjee S, Dey Ghosh R, Ganguly A, Mookerjee. Copper chelate in overcoming MDR in cancer. In: “Metal Ions in Biology and Medicine,” Collery P, Maymard I, Theophanides T, Khassanova L, Collery T (Eds), Vol 10, John Libbey, Eurotext, Paris, 403-412, 2008. (ISBN: 978-2-7420-0714-1).

 

  1. Maitra SK, Chattoraj A, Bhattacharyya S, Dey R. Photoreception and oocyte maturation in a major carp Catla catla: Implication of melatonin and opsin of the pineal organ. In: Tangpraprutgul P. Malaivijitnond S, Kitana N (eds), Comparative Endocrinology and Biodiversity in Asia and Oceania, 55-59, Chulalongkorn University Press, Bangkok. 2006.

 

  1. Chattoraj A, Bhattacharya S, Dey R, Seth M, Maitra SK. Proc Zool Soc. 59: 35-60. 2006 (ISSN: 0373-5893)

 

  1. Bhattacharyya S, Dey R, Maitra SK. Photoperiodic regulation of annual testicular events in the Indian major carp Catla catla. Acta Zoologica, 86, 71-79, 2005. (ISSN: 1463-6395) IF: 1.375

 

  1. Dey R, Bhattacharya S, Maitra SK. Importance of Photoperiods in the Regulation of Ovarian Activities in Major Carp Catla catla in an Annual Cycle. J.Biol. Rhythms. 20, 145-158, 2005. (ISSN: 1552-4531) IF: 2.490

 

  1. Dey R, Bhattacharya S, Maitra SK. Temporal pattern of ovarian activity in a major carp Catla catla and its possible environmental correlate in an annual cycle. Biological Rhythm Research. 35, 329-353, 2004. (ISSN: 0929-1016), IF: 0.826

 

  1. Mukhopadhyay I, Chatterjee A, Maitra SK, Dey R. Histophysiological appraisal of ovarian activity in an Indian major carp in relation to climatological variables: A data based approach. Calcutta Statistical Association Bulletin. 55, 69-90, 2004. (ISSN: 0008-0683).

 

  1. Dey R, Bhattacharya S, Maitra SK, Banerji TK. The morpho-anatomy and histology of the pineal complex in a major Indian Carp, Catla catla: Identification of the pineal photoreceptor cells and their responsiveness to constant light and constant darkness during different phases of the annual reproductive cycle. Endocrine Res. 29:  429-443, 2003. (ISSN: 0743-5800) IF: 1.553

 

  1. Bhattacharya S, Dey R, Basu A, Maitra SK, Banerji TK. The structure of the pineal complex in a common Indian teleost, Catla catla: Evidence for pineal-induced inhibition of testicular function within an annual reproductive cycle. Endocrine Res. 29:  141-156, 2003. (ISSN: 0743-5800) IF: 1.553

 

  1. Maitra SK, Dey R Bhattacharya S. Structural organization and photoresponsive elements of the pineal complex in Indian major carp Catla catla. Proceedings of XXI Natl. Symp. Reprod. Biol. and Comp. Endocrinology on “Recent Advances in Eendocrinology and Reproduction: Evolutionary, Biotechnological and Clinical Implications. 2003. 1-20.

 

  1. Maitra SK, Dey R Bhattacharya S. Seasonal reproduction in fish: A functional interplay between the pineal organ and photoperiods”. J. Endocrinol. Reprod.  5: 1-12, 2001. (ISSN: 2233-4777)

 

  1. Maitra SK , Sengupta A, Bhattacharya S, Dey R. Relative role of the pineal organ and photoperiod in seasonal recovery of spermatogenesis in Roseinged Parakeets. In: “Recent advances in Comp Endocrinol”.(Ed. Yu, JY).  Institute of Zool., Academia Sinica, Taipei, Taiwan, R.O.C., 2001, 434-438.

 

  1. Maitra SK, Dey M, Dutta S, Bhattacharya S, Dey R, Sengupta A. Influences of graded dose of melatonin on the levels of blood glucose and adrenal catecholamines in male roseringed parakeets (Psittacula krameri) under different photoperiods. Arch. Physiol. Biochem. 108:  444-450, 2000. (ISSN: 1381-3455) IF: 1.730

 

  1. Maitra SK, Dey M, Dey R, Bhattacharya S, Sengupta A. Influence of photoperiods on the glycemic and adrenals catecholaminergic responses to melatonin administrations in adult male roseringed parakeets, Psittacula krameri Neumann. Indian J. Exptl. Biol. 38:  1111-1116, 2000. (ISSN: 0019-5189) IF: 1.05

 

  1. Maitra SK, Dey M, Chopra S, Dey R, Sengupta A, Bhattacharya S.  Influences of pinealectomy and exogenous melatonin on the thyroid gland activity varies in relation to reproductive status of spotted munia (Lonchura punctulata; Aves, Passeriformes) in an annual gonadal cycle. Biol. Rhythm Res. 31:  437-449, 2000. (ISSN: 0929-1016), IF: 0.826

 

  1. Maitra SK, Dey M, Panja A, Bhattacharya S, Dey R, Sengupta A. Diurnal profiles of blood glucose in relation to time of administration of melatonin in spotted munia (Lonchura punctulata). Biol. Rhythm Res. 31:  220-229, 2000. (ISSN: 0929-1016), IF: 0.826

 

 

Books/Chapters in books published:

 

  1. Choudhuri SK, Majumder S, Chatterjee S, Dey Ghosh R, Ganguly A, Mookerjee. Copper chelate in overcoming MDR in cancer. In: “Metal Ions in Biology and Medicine,” Collery P, Maymard I, Theophanides T, Khassanova L, Collery T (Eds), Vol 10, John Libbey, Eurotext, Paris, 403-412, 2008. (ISBN: 978-2-7420-0714-1).

 

  1. Maitra SK, Chattoraj A, Bhattacharyya S, Dey R. Photoreception and oocyte maturation in a major carp Catla catla: Implication of melatonin and opsin of the pineal organ. In: Tangpraprutgul P. Malaivijitnond S, Kitana N (eds), Comparative Endocrinology and Biodiversity in Asia and Oceania, 55-59, Chulalongkorn University Press, Bangkok. 2006.

 

  1. Maitra SK, Sengupta A, Bhattacharya S, Dey R. Relative role of the pineal organ and photoperiod in seasonal recovery of spermatogenesis in Roseinged Parakeets. In: “Recent advances in Comp Endocrinol”.(Ed. Yu, JY). Institute of Zool., Academia Sinica, Taipei, Taiwan, R.O.C., 2001, 434-438.

 

Major Research Grants Received as Principal Investigator:

 

  1. Lady Tata Memorial Trust funded IRG grant entitled “A study of prognostic risk-assessment analysis and disease-monitoring through blood-based MALAT1 expression in association with perineural invasion and lympho-vascular invasion in OSCC”. Reference: Approval letter Dated 16th January 2024, (INR 100,000.00) (Ongoing).

 

  1. Proteomic profiling of extracellular vesicles (EVs) to identify markers that may facilitate specific isolation of tumor EVs from patient serum. Proposal id 2021-10960. Sanction letter yet to come. (In collaboration with Dr. Kartiki Desai, NIBMG, Kolkata). (INR 54,36,713/- for 3 years) (Ongoing)

 

  1. Evaluation of the prevalence and prognostic implication of different Consensus Molecular Subtypes of Colorectal tumours in an Eastern India Cohort: A prospective, longitudinal, observational study” Sanction No. 5/4/3-5/Gas/ 2022-NCD-II, dated 08/12/2022 (INR 3100000.00 for 3 years) (As Co-I, Ongoing) (PI Dr. Sudarsana Basu)

 

  1. Lady Tata Memorial Trust funded IRG grant entitled “Evaluation of 5 potential circulating miRNAs (miR-3677-3p, miR-138-5p, miR-3938, miR-4638-3p and miR-4725-3p) as blood-based biomarker for early prediction of disease prognostication in oral cancer”. Reference: Approval letter Dated 14th November 2021, (INR 53,00,179.00) (Ongoing).

 

  1. Grant to support a man power from Lady Tata Memorial Trust (INR 838,856.00) (2019-2020) (Completed).

 

  1. DHR funded HRD WS research grant entitled “MicroRNA profiling for prognostic and predictive biomarker development in patients with oral squamous cell carcinoma”.

 

          Reference No. V.25011/452-HRD/2016-HR, (INR 35,33,796.00)

          Duration: 2017-2020 (Completed).

 

  1. DST funded DST-WOS-A research grant entitled “Studies on regulation of expression of multidrug resistance related genes by key microRNAs in oral squamous cell carcinoma”.

 

          Reference No. SR/WOS-A/LS-316/2011, (INR 23,97,500.00)

          Duration: 2012-2015 (Completed).

 

  1. DST funded DST-WOS-A research grant entitled “Biochemical Modulation of P-glycoprotein to Overcome Multidrug Resistance in Cancer”.

 

          Reference No. SR/WOS-A/LS-89/2007, (INR 18,57,000.00)

          Duration: 2008-2011 (Completed).

 

Life Membership

 

Indian Association of Cancer Research (IACR)

Calcutta Consortium of Human Genetics (CCHuGe)

Society of Biological Chemists (India).

Indian Women Scientist Association (IWSA)

Executive Committee Member of Society of Biological Chemists (I) Kolkata Chapter.

Executive Committee Member of Indian Association of Cancer Research West Bengal Chapter (IACR-WB Chapter)

 

Invited lectures/ Symposia Attended/ Conference Presentations

 

  1. International Onco Summit (NIOS) 2024. Clinical significance of MALAT1 expression in blood plasma in Oral Squamous Cell Carcinoma. Priyanka Adhikary1, Amitabha Dutta2, Subhadeep Karanjai2, Dipti Daga2, Vaibhav Singh2, Alangkar Saha2,
    Zulkarnan Neguive2, Nasir Nabi Naikoo2, Soma Mukhopadhyay1,2, Ruma Dey Ghosh1*
    from 28th -29th January, 2023, Kolkata, India. Poster.

 

  1. International Onco Summit (NIOS) 2024. Characterization of extracellular vesicles from breast cancer cells. Sayan Gharai1, Aritra Gupta1, Ruma Dey Ghosh2, Kartiki Desai1. from 28th -29th January, 2023, Kolkata, India. Poster.

 

  1. One Day Symposium on Emerging areas of cancer therapy and management of drug resistance organized by CNCI in association with the IACR-West Bengal Chapter held at CNCI on 29th November 2023.

 

  1. Two-day symposium on Biological Chemistry at the interface of Research and Translation at NIBMG, Kalyani, jointly organized by SBC(I) Kolkata chapter and NIBMG on 1st & 2nd September 2023.

 

  1. XV TRIENNIAL & III INTERNATIONAL CONFERENCE OF INDIAN WOMEN SCIENTISTS’ ASSOCIATION (IWSA). Ruma Dey Ghosh1*, Priyanka Adhikary1, Vaibhab Singh2, Deepti Daga2, Subhadeep Karanjai2, Harsh Dhar2, Amitabha Dutta2, Akash Bararia3, Pratik Jain3, Kapila Manikantan3, Rajeev Sharan3, Indranil Mukhopadhyay4, Soma Mukhopadhyay1,2, Pattatheyil Arun3. Evaluation of potential candidate of circulating miRNAs from plasma to be a molecular biomarker for early prediction of disease recurrence in oral squamous cell carcinoma. June 11-13, 2023 at Vashi, Navi Mumbai. Poster.

 

  1. XV TRIENNIAL & III INTERNATIONAL CONFERENCE OF INDIAN WOMEN SCIENTISTS’ ASSOCIATION (IWSA). Priyanka Adhikary1, Vaibhab Singh2, Deepti Daga2, Subhadeep Karanjai2, Harsh Dhar2, Amitabha Dutta2, Soma Mukhopadhyay1,2, Ruma Dey Ghosh1 MALAT1: A clinically significant circulatory cell-free long noncoding RNA as an independent biomarker for better prognostication compared to the conventional histopathological markers in patients with oral squamous cell carcinoma. June 11-13, 2023 at Vashi, Navi Mumbai. Poster.

 

  1. International Onco Summit 2023. Priyanka Adhikary, Vaibhab Singh, Deepti Daga, Subhadeep Karanjai, Harsh Dhar, Amitabha Dutta, Soma Mukhopadhyay, Ruma Dey Ghosh*. Clinical significance of circulating cell-free lncRNA MALAT1 and its correlation with histopathological markers for risk-stratification of patients with oral squamous cell carcinoma. Organized by Netaji Subhas Chandra Bose Cancer Hospital, at Ozone Convention Center, Newtown, Kolkata-700156, on 28th and 29th January 2023. Poster presentation by my PhD student. * Corresponding author.

 

  1. International Onco Summit 2023. Sumon Mukherjee, Subhadip Pati, Saikat Dutta, Pratyush Datta, Jayati Chakraborty, Ruma Dey Ghosh, and Gourisankar Sa*. Developmental and functional attributes of B-regulatory cell in tumour microenvironment. Organized by Netaji Subhas Chandra Bose Cancer Hospital, at Ozone Convention Center, Newtown, Kolkata-700156, on 28th and 29th January 2023. Poster presentation. * Corresponding author.

 

  1. International Onco Summit 2023. Saikat Dutta, Sumon Mukherjee, Subhadip Pati, Pratyush Datta, Jayati Chakraborty, Ruma Dey Ghosh, and Gourisankar Sa*. Phenotypical and functional characterization of PD-1+ breast tumor-associated T-regulatory cells. Organized by Netaji Subhas Chandra Bose Cancer Hospital, at Ozone Convention Center, Newtown, Kolkata-700156, on 28th and 29th January 2023. Poster presentation. * Corresponding author.

 

  1. International Onco Summit 2023. Arijit Ghosh, Amitabha Dutta Tania Sarkar, Anewesha Mukherjee, Himika Mukhopadhyay, Ruma Dey Ghosh, Rittwika Bhattacharya, Soma Mukhopadhyay. Aberrant expression of CD markers in Acute leukemia: An eight-month study in Netaji Subhas Chandra Bose Cancer Hospital. Organized by Netaji Subhas Chandra Bose Cancer Hospital, at Ozone Convention Center, Newtown, Kolkata-700156, on 28th and 29th January 2023. Poster presentation. * Corresponding author.

 

  1. International Onco Summit 2023. Ruma Dey Ghosh as moderator of a Panel discussion on “Recent advancements in precision medicine and translational cancer biology.” Organized by Netaji Subhas Chandra Bose Cancer Hospital, at Ozone Convention Center, Newtown, Kolkata-700156, on 28th and 29th January 2023. Moderator of a Panel discussion.

 

  1. 91st Annual Meeting of Society of Biological Chemists (India) on “Life at the Confluence of Biology and Chemistry”. Priyanka Adhikary1, Vaibhab Singh2, Deepti Daga2, Subhadip Karanjai2, Harsh Dhar2, Amitabha Dutta2, Soma Mukhopadhyay1,2, Ruma Dey Ghosh1*. Evaluation of circulating cell-free long non-coding RNA MALAT1 as blood-based biomarkers for liquid biopsy for the early prediction of prognosis in oral squamous cell carcinoma.” 8 th -11th December, 2022, Kolkata, India. Poster presentation by my PhD student. * Corresponding author.

 

  1. 91st Annual Meeting of Society of Biological Chemists (India) on “Life at the Confluence of Biology and Chemistry”. 8 th -11th December, 2022, Kolkata, India. Ruma Dey Ghosh as one of the organizing committee members and poster judges.

 

  1. Invited special lecture on Finding foothold in higher education in India by Dr. Ruma Dey Ghosh. AIPCWB Education Seminar On “Innovative Education in Pleasant Environment” at Hotel Lindsay, Lindsay Street, Newmarket, Kolkata, West Bengal, India on 26th November, 2022. Invited speaker, panelist in a panel discussion.

 

  1. Invited special lecture on “Identification of miRNAs as a blood-based biomarker for liquid biopsy using blood sample for the prediction of prognosis in oral squamous cell carcinoma” organized by CNCB Academy of Science and Technology Jagatsinghpur, Odisha, 1st December, 2021. Invited special lecture.

 

  1. Invited special lecture on “Circulating microRNA as a blood-based biomarker for the prediction of prognosis in oral squamous cell carcinoma” organized by Department of Biotechnology, University of Engineering & Management, Kolkata, 16th of August, 2021. Invited special lecture.

 

  1. One-day mini symposium on “Bridging chemistry and biology for human Health and diseases” organized by Society of Biological Chemists (I) Kolkata Chapter & CSIR-Indian Institute of Chemical Biology at CSIR-IICB, Jadavpur on September 21st, 2019. Participant

 

  1. BIOSPECTRUM, the International Conference on Biotechnology and Biological Sciences (BIOSPECTRUM 2019). Ruma Dey Ghosh. MicroRNAs: alter their expression profile as per cellular needs and cellular responses, to decide cell fate as discovered in cisplatin-resistance oral squamous cell carcinoma. University of Engineering & Management, Kolkata, 8th-10th of August, 2019. Invited speaker, chairperson for a session (oral presentation) and judge for a poster session.

 

 

  1. BIOSPECTRUM, the International Conference on Biotechnology and Biological Sciences (BIOSPECTRUM 2019). Ghosh RD, Bararia A, Majumder SG, Manickam A, Bhutia TY, Biswas S, Jain P, Manikantan K, Sharan R, Arun P. Cell-free mature miR-100-5p expression in plasma and its correlation with the histopathological markers in oral squamous cell carcinoma. University of Engineering & Management, Kolkata, 8th-10th of August, 2019. Oral presentation by Akash Bararia

 

  1. 38th Annual Convention of Association for Cancer Research (IACR 2019) on Integrating Cancer Research into Comprehensive Disease Management: Recent Breakthroughs. Ruma Dey Ghosh. Cancer cell fine-tunes microRNA expression profile to develop cisplatin-resistance by uplifting cancer stem-cell and epithelial-mesenchymal-transition properties: An oral squamous cell carcinoma scenario. PGIMER Chandigarh at Hotel Mountview, Chandigarh, 1st - 3rd March 2019. Invited speaker and judge for a poster session.

 

  1. 10th East Zonal Oncology Symposium on Clinical and molecular advances in gynaecological cancers. Saroj Gupta Cancer Centre and Research Institute, Kolkata, 19th January, 2019. Participant.

 

  1. 37th Annual convention of Indian Association for Cancer Research on “From Cancer Biology to Precision Oncology: Challenges and Considerations”. Ghosh RD, Ghuwalewala S, Das P, Mandoloi S, Alam SK, Chakraborty J, Sarkar S, Chakraborty S, Panda CK and Roychoudhury S. MicroRNAs contribute to cisplatin resistance through enrichment of cancer-stem-cell and epithelial-mesenchymal-transition in oral squamous cell carcinoma Bose Institute, Kolkata, February 23-25, 2018. Poster presentation.

 

  1. 3rdInternational Conference on Translational Research: Application in Human Health and Agriculture. Amity University, Kolkata on 23-25 September, 2017. Participant

 

  1. 4th International Conference on Angiogenesis Research: Anti-Angiogenic Therapy in Human Diseases. Saroj Gupta Cancer Centre and Research Institute on 21st September 2017. Participant

 

  1. 1st Annual Cancer Biobanking Workshop 2017. Tata Medical Center, Kolkata. 12th -13th January, 2017. Participant.
Name
Mobile
Location

Book Online